Hydrochloric Acid → HCID 87628703, compound

HRID 1970032Notes

Reaction equation

HRID 1970032 reaction equation
C(O[C:6]([N:8](C)[CH2:9][CH2:10][N:11]([CH2:29][C:30]#[CH:31])[S:12]([C:15]1[CH:24]=[CH:23][C:22]2[NH:21][C:20](=[O:25])[C:19]3[NH:26][CH:27]=[CH:28][C:18]=3[C:17]=2[CH:16]=1)(=[O:14])=[O:13])=O)(C)(C)C.[CH2:33]([C:36]([O-:38])=[O:37])[CH2:34][CH3:35].[ClH:39]>C(OCC)C>[CH3:6][NH:8][CH2:9][CH2:10][N:11]([CH2:29][C:30]#[CH:31])[S:12]([C:15]1[CH:24]=[CH:23][C:22]2[NH:21][C:20](=[O:25])[C:19]3[NH:26][CH:27]=[CH:28][C:18]=3[C:17]=2[CH:16]=1)(=[O:14])=[O:13].[ClH:39].[CH2:33]([C:36]([OH:38])=[O:37])[CH2:34][CH3:35]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 131730524HCID 131730524, compound

Product 1

HCID 87628703HCID 87628703, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

This compound is prepared according to synthesis 139, from 54 mg (0.1 mmol) of 8-{[2-(tert-butoxycarbonyl-methyl-amino)-ethyl]-prop-2-ynyl-sulfamoyl}-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-propyl carboxylate and 2.5 mL (5 mmol) of a 2M solution of hydrochloric acid in diethyl ether to give, after filtration, 42 mg (87%) of 8-[(2-methylamino-ethyl)-prop-2-ynyl-sulfamoyl]-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-propyl carboxylate hydrochloride in the form of a white solid.

Workup

  1. customThis compound is prepared
  2. customto give
  3. filtrationafter filtration, 42 mg (87%) of 8-[(2-methylamino-ethyl)-prop-2-ynyl-sulfamoyl]-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-propyl carboxylate hydrochloride in the form of a white solid

Sources & evidence

ORD record
ord-ebe96648579a44099b03d01b85a30cb4
Source dataset
uspto-grants-2013_04
Patent number
US08426437B2

Reaction notes

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