Hydrochloric Acid → HCID 87629037, compound

HRID 1970034Notes

Reaction equation

HRID 1970034 reaction equation
C(OC([N:8]([CH:32]([CH3:34])[CH3:33])[CH2:9][CH2:10][N:11]([CH2:29][C:30]#[CH:31])[S:12]([C:15]1[CH:24]=[CH:23][C:22]2[NH:21][C:20](=[O:25])[C:19]3[NH:26][CH:27]=[CH:28][C:18]=3[C:17]=2[CH:16]=1)(=[O:14])=[O:13])=O)(C)(C)C.[CH2:35]([C:38]([O-:40])=[O:39])[CH2:36][CH3:37].[ClH:41]>C(OCC)C>[CH:32]([NH:8][CH2:9][CH2:10][N:11]([CH2:29][C:30]#[CH:31])[S:12]([C:15]1[CH:24]=[CH:23][C:22]2[NH:21][C:20](=[O:25])[C:19]3[NH:26][CH:27]=[CH:28][C:18]=3[C:17]=2[CH:16]=1)(=[O:14])=[O:13])([CH3:34])[CH3:33].[ClH:41].[CH2:35]([C:38]([OH:40])=[O:39])[CH2:36][CH3:37]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 131730525HCID 131730525, compound

Product 1

HCID 87629037HCID 87629037, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

This compound is prepared according to synthesis 139, from 57 mg (0.1 mmol) of 8-{[2-(tert-butoxycarbonyl-isopropyl-amino)-ethyl]-prop-2-ynyl-sulfamoyl}-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-propyl carboxylate and 2.5 mL (5 mmol) of a 2M solution of hydrochloric acid in diethyl ether to give, after filtration, 42 mg (82%) of 8-[(2-isopropylamino-ethyl)-prop-2-ynyl-sulfamoyl]-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-propyl carboxylate hydrochloride in the form of a white solid.

Workup

  1. customThis compound is prepared
  2. customto give
  3. filtrationafter filtration, 42 mg (82%) of 8-[(2-isopropylamino-ethyl)-prop-2-ynyl-sulfamoyl]-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-propyl carboxylate hydrochloride in the form of a white solid

Sources & evidence

ORD record
ord-2ace35af7448425bb174e84df885d42d
Source dataset
uspto-grants-2013_04
Patent number
US08426437B2

Reaction notes

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