Triethylamine → 8-[3-(tert-Butoxycarbonyl-methyl-amino)-pyrrolidine-1-sulfonyl]-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline 1-propyl carboxylate

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This compound was prepared according to general method of esterification C from 294 mg (0.6 mmol) of 8-[3-(tert-butoxycarbonyl-methyl-amino)-pyrrolidine-1-sulfonyl]-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-carboxylic acid, 836 μL (6 mmol) of triethylamine and 492 μL (3 mmol) of di-n-propylsulfate to give, after purification by chromatography on silica (eluent dichloromethane/methanol 98/2), 155 mg (50%) of 8-[3-(tert-butoxycarbonyl-methyl-amino)-pyrrolidine-1-sulfonyl]-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-propyl carboxylate in the form of a brown solid.

Provenance & Evidence