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HRID1970037

反应详情

EQUATION

反应方程式

HRID 1970037 的结构方程式

REACTANTS

反应物

3
结构：CCN(CC)CC
HCID8471

Triethylamine

C6H15N

结构：CCCOS(=O)(=O)OCCC
HCID69015

Sulfuric acid, dipropyl ester

C6H14O4S

结构：CN(C(=O)OC(C)(C)C)C1CCN(S(=O)(=O)c2ccc3[nH]c(=O)c4[nH]cc(C(=O)O)c4c3c2)C1
HCID57575984

未命名化合物

PRODUCTS

生成物

1
结构：CCCC(=O)[O-].CN(C(=O)OC(C)(C)C)C1CCN(S(=O)(=O)c2ccc3[nH]c(=O)c4[nH]ccc4c3c2)C1
HCID86627535

未命名化合物

PROCEDURE

实验过程

This compound was prepared according to general method of esterification C from 294 mg (0.6 mmol) of 8-[3-(tert-butoxycarbonyl-methyl-amino)-pyrrolidine-1-sulfonyl]-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-carboxylic acid, 836 μL (6 mmol) of triethylamine and 492 μL (3 mmol) of di-n-propylsulfate to give, after purification by chromatography on silica (eluent dichloromethane/methanol 98/2), 155 mg (50%) of 8-[3-(tert-butoxycarbonyl-methyl-amino)-pyrrolidine-1-sulfonyl]-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-propyl carboxylate in the form of a brown solid.

WORKUP

后处理

  1. customThis compound was prepared
  2. customto give
  3. customafter purification by chromatography on silica (eluent dichloromethane/methanol 98/2), 155 mg (50%) of 8-[3-(tert-butoxycarbonyl-methyl-amino)-pyrrolidine-1-sulfonyl]-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-propyl carboxylate in the form of a brown solid