反应详情

A suspension of 47 mg (0.14 mmol) of 8-(3-hydroxy-3-methyl-but-1-ynyl)-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate, 164 mg (2.6 mmol) of ammonium formate and 5 mg of palladium on charcoal in 10 ml of ethanol is refluxed for 8 hours. The solution is filtered on celite and then evaporated. Water is added and the product is extracted twice with ethyl acetate. The organic phases are dried over magnesium sulfate, filtered and evaporated to give 5 mg (10%) of 8-(3-hydroxy-3-methyl-butyl)-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate in the form of a colourless oil.

1. temperatureis refluxed for 8 hours
2. filtrationThe solution is filtered on celite
3. customevaporated
4. additionWater is added
5. extractionthe product is extracted twice with ethyl acetate
6. dry with materialThe organic phases are dried over magnesium sulfate
7. filtrationfiltered
8. customevaporated