Triethylamine → HCID 86627561, compound

HRID 1970057Notes

Reaction equation

HRID 1970057 reaction equation
[O:1]=[C:2]1[C:11]2[NH:12][CH:13]=[C:14]([C:15]([OH:17])=[O:16])[C:10]=2[C:9]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[NH:3]1.C(N(CC)CC)C.C(OS(OCCC)(=O)=O)CC>>[O:1]=[C:2]1[C:11]2[NH:12][CH:13]=[CH:14][C:10]=2[C:9]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[NH:3]1.[CH2:14]([C:15]([O-:17])=[O:16])[CH2:10][CH3:9]

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 69015Sulfuric acid, dipropyl esterHCID 120650844-oxo-3H,4H,5H-pyrrolo[2,3-c]quinoline-1-carboxylic acid

Product 1

HCID 86627561HCID 86627561, compound

Procedure

4-Oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-propyl carboxylate was prepared according to method of esterification C from 194 mg (0.85 mmol) of 4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-carboxylic acid, 1.29 mL (12.75 mmol) of triethylamine and 698 μL (1.1 mmol) of di-n-propylsulfate to give, after precipitation in water, 200 mg (87%) of 4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-propyl carboxylate in the form of a beige solid.

Workup

  1. customto give
  2. customafter precipitation in water

Sources & evidence

ORD record
ord-884c9315a02646e08cdc0ff266c54687
Source dataset
uspto-grants-2013_04
Patent number
US08426437B2

Reaction notes

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