Guanidine Hydrochloride → HCID 86627578, compound

Participants

Reaction Conditions

Reaction Steps

83 mg (0.87 mmol) of guanidine hydrochloride is added to a suspension of 204 mg (0.58 mmol) of 8-(3-dimethylamino-acryloyl)-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate in 2.3 mL of anhydrous dimethylacetamide. The mixture is stirred at 130° C. for 4 days then the solvent is evaporated. The residue is triturated with methanol to give a solid which is collected by filtration then washed with methanol and then diisopropyl ether. After drying, 114 mg (56%) of 8-(2-amino-pyrimidin-4-yl)-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate is obtained in the form of a brown solid.

Provenance & Evidence