反应详情

温度

90 °C

17 mg (1.5 mmol) of thioacetamide is added to a suspension of 57 mg (0.15 mmol) of 8-(2-bromo-acetyl)-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate in 3 mL of ethanol. The mixture is stirred at 90° C. for 3 hours then the mixture is cooled to room temperature. Triethylamine (2 mmol) is added, then the solvent is evaporated and the product is purified by chromatography on silica (chloroform/methanol 95/5). After drying, 18 mg (34%) of 8-(2-methyl-thiazol-4-yl)-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate is obtained in the form of a beige solid.

1. temperaturethe mixture is cooled to room temperature
2. customthe solvent is evaporated
3. customthe product is purified by chromatography on silica (chloroform/methanol 95/5)
4. customAfter drying