Diethanolamine → 2-[Bis-(2-hydroxy-ethyl)-amino]-5-[1-(4-chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-thiazol-4-one

HRID 1970119Notes

Reaction equation

HRID 1970119 reaction equation
[Cl:1][C:2]1[CH:27]=[CH:26][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([CH:16]=[C:17]4[S:21][CH:20](SCC)[NH:19][C:18]4=[O:25])=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:28]([F:31])([F:30])[F:29])[CH:3]=1.[OH:32][CH2:33][CH2:34][NH:35][CH2:36][CH2:37][OH:38]>>[OH:32][CH2:33][CH2:34][N:35]([CH2:36][CH2:37][OH:38])[C:20]1[S:21][C:17](=[CH:16][C:12]2[CH:11]=[C:10]3[C:15](=[CH:14][CH:13]=2)[N:7]([CH2:6][C:5]2[CH:26]=[CH:27][C:2]([Cl:1])=[CH:3][C:4]=2[C:28]([F:31])([F:30])[F:29])[N:8]=[CH:9]3)[C:18](=[O:25])[N:19]=1

Participants

3

Reactant 2

HCID 8113DiethanolamineHCID 866565235-[1-(4-chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-ethylsulfanyl-thiazolidin-4-one

Product 1

HCID 673465612-[Bis-(2-hydroxy-ethyl)-amino]-5-[1-(4-chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-thiazol-4-one

Procedure

2-[Bis-(2-hydroxy-ethyl)-amino]-5-[1-(4-chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-thiazol-4-one was prepared from 5-[1-(4-chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-ethylsulfanyl-thiazolidin-4-one and 2-(2-Hydroxy-ethylamino)-ethanol following General Procedure C.

Sources & evidence

ORD record
ord-75786562cdc0451db3d0987cf3993299
Source dataset
uspto-grants-2013_04
Patent number
US08426604B2

Reaction notes

Loading…