HRID1970166

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID17998751

1-[1-(2-Methoxyethyl)pyrrolidin-3-yl]-N-methylmethanamine

C9H20N2O

结构：CCCSC1NC(=O)C(=Cc2ccc3c(cnn3Cc3ccc(Cl)cc3C(F)(F)F)c2)S1

HCID86656530

未命名化合物

PRODUCTS

生成物

结构：COCCN1CCC(CN(C)C2=NC(=O)C(=Cc3ccc4c(cnn4Cc4ccc(Cl)cc4C(F)(F)F)c3)S2)C1

HCID67348856

未命名化合物

PROCEDURE

实验过程

5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-{[1-(2-methoxy-ethyl)-pyrrolidin-3-ylmethyl]-methyl-amino}-thiazol-4-one was prepared from 5-[1-(4-chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-propylsulfanyl-thiazolidin-4-one and [1-(2-Methoxy-ethyl)-pyrrolidin-3-ylmethyl]-methyl-amine following General Procedure B.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-af1b6f7244a94efab5974d90dcbd0c34
来源数据集: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08426604B2
来源说明: uspto-grants-2013_04

反应 SMILES

[Cl:1][C:2]1[CH:28]=[CH:27][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([CH:16]=[C:17]4[S:21][CH:20](SCCC)[NH:19][C:18]4=[O:26])=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:29]([F:32])([F:31])[F:30])[CH:3]=1.[CH3:33][O:34][CH2:35][CH2:36][N:37]1[CH2:41][CH2:40][CH:39]([CH2:42][NH:43][CH3:44])[CH2:38]1>>[Cl:1][C:2]1[CH:28]=[CH:27][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([CH:16]=[C:17]4[S:21][C:20]([N:43]([CH2:42][CH:39]5[CH2:40][CH2:41][N:37]([CH2:36][CH2:35][O:34][CH3:33])[CH2:38]5)[CH3:44])=[N:19][C:18]4=[O:26])=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:29]([F:31])([F:32])[F:30])[CH:3]=1