HRID1970432

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID244

Benzyl alcohol

C7H8O

HCID6228

N,N-Dimethylformamide

C3H7NO

HCID6992152

未命名化合物

HCID86609523

未命名化合物

结构：CCOC(=O)N1CCN(C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)c2cc(O)cc(-c3ccccc3)n2)CC1

HCID178473387

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)N1CCN(C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)c2cc(O[C@@H](C)C(=O)OCc3ccccc3)n(-c3ccccc3)n2)CC1

HCID66854757

未命名化合物

PROCEDURE

实验过程

To a solution of 4.00 g 4-{(S)-4-tert-Butoxycarbonyl-2-[(4-hydroxy-6-phenyl-pyridine-2-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid ethyl ester in 30 ml DMF were added 1.84 g (R)-2-bromo-propionic acid benzyl ester (prepared by standard benzylation procedure using (R)-2-bromopropionic acid and benzyl alcohol

WORKUP

后处理

customprepared by standard benzylation procedure

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-2ef0c71c63d04173990e034f890f894d
来源数据集: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08426420B2
来源说明: uspto-grants-2013_04

反应 SMILES

[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][N:9]([C:12](=[O:39])[C@@H:13]([NH:23][C:24]([C:26]2[CH:31]=[C:30]([OH:32])C=C(C3C=CC=CC=3)[N:27]=2)=[O:25])[CH2:14][CH2:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:8][CH2:7]1)=[O:5])[CH3:2].[CH2:40]([O:47][C:48](=[O:52])[C@H:49](Br)[CH3:50])[C:41]1[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=1.Br[C@H](C)C(O)=O.C(O)[C:60]1[CH:65]=[CH:64][CH:63]=[CH:62][CH:61]=1.C[N:68](C=O)C>>[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][N:9]([C:12](=[O:39])[C@@H:13]([NH:23][C:24]([C:26]2[CH:31]=[C:30]([O:32][C@H:49]([C:48]([O:47][CH2:40][C:41]3[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=3)=[O:52])[CH3:50])[N:68]([C:60]3[CH:61]=[CH:62][CH:63]=[CH:64][CH:65]=3)[N:27]=2)=[O:25])[CH2:14][CH2:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:8][CH2:7]1)=[O:5])[CH3:2]