3-Benzyloxycarbonylamino-pyrrolidine-1-carboxylic acid butyl ester → Butyl 3-aminopyrrolidine-1-carboxylate

HRID 1970473Notes

Reaction equation

HRID 1970473 reaction equation
[CH2:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH:10]([NH:13]C(OCC2C=CC=CC=2)=O)[CH2:9]1)=[O:7])[CH2:2][CH2:3][CH3:4]>C(OCC)(=O)C.[Pd]>[CH2:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH:10]([NH2:13])[CH2:9]1)=[O:7])[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 1

HCID 668545503-Benzyloxycarbonylamino-pyrrolidine-1-carboxylic acid butyl ester

Product 1

HCID 11608053Butyl 3-aminopyrrolidine-1-carboxylate

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

A solution of 467 mg 3-benzyloxycarbonylamino-pyrrolidine-1-carboxylic acid butyl ester in 10 ml ethyl acetate was stirred in the presence of 50 mg Pd/C (10%) under an atmosphere of hydrogen (1 bar) for 12 h. The reaction mixture was filtrated, washed with ethyl acetate and concentrated to give the title compound as colorless oil.

Workup

  1. filtrationThe reaction mixture was filtrated
  2. washwashed with ethyl acetate
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-5f9f7a17b08d4ee288852c9c73d4bca8
Source dataset
uspto-grants-2013_04
Patent number
US08426420B2

Reaction notes

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