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HRID1970500

反应详情

EQUATION

反应方程式

HRID 1970500 的结构方程式

REACTANTS

反应物

2
结构：Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1
HCID466102

未命名化合物

结构：CCOC(=O)N1CCN(C(=O)[C@H](CC2COC(C)(C)O2)NC(=O)c2cc(OCC(=O)N3CCC[C@H]3C(=O)NC3CCC3)n(-c3ccccc3)n2)CC1
HCID66855096

未命名化合物

PRODUCTS

生成物

1
结构：CCOC(=O)N1CCN(C(=O)[C@H](CC(O)CO)NC(=O)c2cc(OCC(=O)N3CCC[C@H]3C(=O)NC3CCC3)n(-c3ccccc3)n2)CC1
HCID66856192

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

To a solution of 15 mg 4-[(S)-2-({5-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]-1-phenyl-1H-pyrazole-3-carbonyl}-amino)-3-(2,2-dimethyl-[1,3]dioxolan-4-yl)-propionyl]-piperazine-1-carboxylic acid ethyl ester in 5 ml MeOH were added 5 mg pyridinium p-toluenesulfonate and the solution was stirred for 2 h before being concentrated in vacuo. The residue thus obtained was purified by preparative HPLC (C18 reverse phase column, elution with a water/MeCN gradient with 0.1% TFA). The fractions containing the product were lyophilized to yield the pure product.

WORKUP

后处理

  1. concentrationbefore being concentrated in vacuo
  2. customThe residue thus obtained
  3. customwas purified by preparative HPLC (
  4. washC18 reverse phase column, elution with a water/MeCN gradient with 0.1% TFA)
  5. additionThe fractions containing the product
  6. customto yield the pure product