Trifluoroacetic acid → Butyl piperazine-1-carboxylate

HRID 1970502Notes

Reaction equation

HRID 1970502 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]([O:16][CH2:17][CH2:18][CH2:19][CH3:20])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>ClCCl>[CH2:17]([O:16][C:14]([N:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)=[O:15])[CH2:18][CH2:19][CH3:20]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66855304HCID 66855304, compound

Product 1

HCID 21963126Butyl piperazine-1-carboxylate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 18.0 g piperazine-1,4-dicarboxylic acid butyl ester tert-butyl ester in 70 ml dichloromethane were added 23 ml TFA. After stirring for 12 h the solution was concentrated and the residue codistilled with toluene twice. Yield: 18.5 g.

Workup

  1. concentrationwas concentrated

Sources & evidence

ORD record
ord-7b4409261db74d6d9c4d08bed2c1df7d
Source dataset
uspto-grants-2013_04
Patent number
US08426420B2

Reaction notes

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