HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Trifluoroacetic acid → Benzyl (2S)-2-methylpiperazine-1-carboxylate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Trifluoroacetic acid | HCID 6422 | — |
| Edukt | 1-benzyl 4-(tert-butyl) (S)-2-methylpiperazine-1,4-dicarboxylate | HCID 29921716 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | Benzyl (2S)-2-methylpiperazine-1-carboxylate | HCID 40425199 | — |
Reaktionsschritte
A solution of 4.3 g (S)-2-Methyl-piperazine-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester in 20 ml dichloromethane was stirred in the presence of 10 ml TFA for 16 h. The solution was concentrated and the residue codistilled twice with toluene to give the crude hydrotrifluoroacetate. Yield: 6.4 g.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08426420B2 |
| Quelldatensatz | uspto-grants-2013_04 |
| ORD ID | ord-31083060ec4546e6bb1e81dcf4886988 |
| Quellennotiz | uspto-grants-2013_04 |