Trifluoroacetic acid → Benzyl (2S)-2-methylpiperazine-1-carboxylate

HRID 1970546ノート

反応式

HRID 1970546 の反応式
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]([O:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[O:15])[C@@H:10]([CH3:24])[CH2:9]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>ClCCl>[CH2:17]([O:16][C:14]([N:11]1[CH2:12][CH2:13][NH:8][CH2:9][C@@H:10]1[CH3:24])=[O:15])[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 29921716HCID 29921716、化合物

生成物 1

HCID 40425199Benzyl (2S)-2-methylpiperazine-1-carboxylate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of 4.3 g (S)-2-Methyl-piperazine-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester in 20 ml dichloromethane was stirred in the presence of 10 ml TFA for 16 h. The solution was concentrated and the residue codistilled twice with toluene to give the crude hydrotrifluoroacetate. Yield: 6.4 g.

後処理

  1. concentrationThe solution was concentrated
  2. customto give the crude hydrotrifluoroacetate

出典と根拠

ORDレコード
ord-31083060ec4546e6bb1e81dcf4886988
出典データセット
uspto-grants-2013_04
特許番号
US08426420B2

反応ノート

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