Trifluoroacetic acid → Phenyl piperazine-1-carboxylate

HRID 1970551Notes

Reaction equation

HRID 1970551 reaction equation
[C:1]1([O:7][C:8]([N:10]2[CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][CH2:11]2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(O)(C(F)(F)F)=O>ClCCl>[C:1]1([O:7][C:8]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 11529616Piperazine-1,4-dicarboxylic acid tert-butyl ester phenyl ester

Product 1

HCID 14896427Phenyl piperazine-1-carboxylate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Crude piperazine-1,4-dicarboxylic acid tert-butyl ester phenyl ester was dissolved in 10 ml dichloromethane and treated with 4 ml TFA. After stirring for 12 h the solution was concentrated and the residue codistilled twice with toluene. Yield: 3.0 g.

Workup

  1. concentrationwas concentrated

Sources & evidence

ORD record
ord-e7e491c331a6439296bf72d1f0a0e72f
Source dataset
uspto-grants-2013_04
Patent number
US08426420B2

Reaction notes

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