Trifluoroacetic acid → Propyl piperazine-1-carboxylate

HRID 1970555Notes

Reaction equation

HRID 1970555 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]([O:16][CH2:17][CH2:18][CH3:19])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>ClCCl>[CH2:17]([O:16][C:14]([N:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)=[O:15])[CH2:18][CH3:19]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66854950Piperazine-1,4-dicarboxylic acid propyl ester tert-butyl ester

Product 1

HCID 22393735Propyl piperazine-1-carboxylate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 7.5 g piperazine-1,4-dicarboxylic acid propyl ester tert-butyl ester in 70 ml dichloromethane were added 10 ml TFA. After stirring for 36 h the solution was concentrated and the residue codistilled with toluene twice. Yield: 9.2 g.

Workup

  1. concentrationwas concentrated

Sources & evidence

ORD record
ord-a220378d76da47c3bf7c8799b5657dff
Source dataset
uspto-grants-2013_04
Patent number
US08426420B2

Reaction notes

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