反应详情

A suspension of 5.90 g piperazine-1,4-dicarboxylic acid benzyl ester cyclobutyl ester and 0.25 g Pd/C (10%) in 50 ml ethyl acetate was stirred under an atmosphere of hydrogen (3 bar) for 12 h. The mixture was filtrated over a plug of Celite, washed with ethyl acetate and the combined wash solutions concentrated to give the title compound as colourless oil.

1. filtrationThe mixture was filtrated over a plug of Celite
2. washwashed with ethyl acetate
3. concentrationthe combined wash solutions concentrated