HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → methyl (2S)-4,4-difluoropyrrolidine-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | N-Boc-4,4-difluoro-L-proline methyl ester | HCID 11129200 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | methyl (2S)-4,4-difluoropyrrolidine-2-carboxylate | HCID 45082563 | — |
Reaction Steps
To a solution of 650 mg (S)-4,4-Difluoro-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester in 10 ml dichloromethane were added 1.5 ml TFA. After stirring for 12 h the solution was concentrated to give the crude hydrotrifluoroacetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08426420B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-c7223e67b1ce40bc8aa1108b61a1ae13 |
| Source note | uspto-grants-2013_04 |