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HRID1970561

反应详情

EQUATION

反应方程式

HRID 1970561 的结构方程式

REACTANTS

反应物

2
结构：O=C(O)C(F)(F)F
HCID6422

未命名化合物

结构：COC(=O)[C@@H]1CC(F)(F)CN1C(=O)OC(C)(C)C
HCID11129200

1-tert-Butyl 2-methyl (2S)-4,4-difluoropyrrolidine-1,2-dicarboxylate

C11H17F2NO4

PRODUCTS

生成物

1
结构：COC(=O)[C@@H]1CC(F)(F)CN1
HCID45082563

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

To a solution of 650 mg (S)-4,4-Difluoro-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester in 10 ml dichloromethane were added 1.5 ml TFA. After stirring for 12 h the solution was concentrated to give the crude hydrotrifluoroacetate.

WORKUP

后处理

  1. concentrationwas concentrated
  2. customto give the crude hydrotrifluoroacetate