4-(Trifluoromethyl)phenylhydrazine → HCID 178469353, compound

HRID 1970584Notes

Reaction equation

HRID 1970584 reaction equation
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:8]=[CH:7][C:6]([NH:9][NH2:10])=[CH:5][CH:4]=1.[Na].[C:14](OCC)(=[O:23])[CH2:15][C:16]([C:18]([O:20][CH2:21][CH3:22])=[O:19])=O>C(O)(=O)C>[CH2:21]([O:20][C:18]([C:16]1[CH:15]=[C:14]([OH:23])[N:9]([C:6]2[CH:5]=[CH:4][C:3]([C:2]([F:11])([F:12])[F:1])=[CH:8][CH:7]=2)[N:10]=1)=[O:19])[CH3:22]

Participants

4

Reactant 2

HCID 1362004-(Trifluoromethyl)phenylhydrazineHCID 57351814Diethyl 2-oxosuccinate,sodium salt

Product 1

HCID 178469353HCID 178469353, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 6.83 g 4-(trifluoromethyl)phenylhydrazine and 9.05 g diethyl oxalacetate sodium salt in 120 ml acetic acid was stirred at 100° C. for 2 h. The product precipitated was filtered, codistilled twice with toluene and suspended with heptane/ethyl acetate 3:1. The suspension was filtered again and the cude product obtained dried in vacuo.

Workup

  1. customThe product precipitated
  2. filtrationwas filtered
  3. filtrationThe suspension was filtered again
  4. customthe cude product obtained
  5. customdried in vacuo

Sources & evidence

ORD record
ord-a6b662f9f8f4432fa5fb3afddc7826d4
Source dataset
uspto-grants-2013_04
Patent number
US08426420B2

Reaction notes

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