Trifluoroacetic acid → HCID 66855161, compound

HRID 1970589Notes

Reaction equation

HRID 1970589 reaction equation
C([O:5][C:6](=[O:38])[CH2:7][NH:8][C:9]([C:11]1[CH:15]=[C:14]([O:16][CH2:17][C:18]([N:20]2[CH2:24][CH2:23][CH2:22][C@H:21]2[C:25](=[O:31])[NH:26][CH:27]2[CH2:30][CH2:29][CH2:28]2)=[O:19])[N:13]([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[N:12]=1)=[O:10])(C)(C)C.C(O)(C(F)(F)F)=O>ClCCl>[CH:27]1([NH:26][C:25]([C@@H:21]2[CH2:22][CH2:23][CH2:24][N:20]2[C:18](=[O:19])[CH2:17][O:16][C:14]2[N:13]([C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)[N:12]=[C:11]([C:9]([NH:8][CH2:7][C:6]([OH:38])=[O:5])=[O:10])[CH:15]=2)=[O:31])[CH2:30][CH2:29][CH2:28]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66854954HCID 66854954, compound

Product 1

HCID 66855161HCID 66855161, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 1.33 g ({5-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]-1-phenyl-1H-pyrazole-3-carbonyl}-amino)-acetic acid tert-butyl ester in 20 ml dichloromethane were added 3.8 ml TFA. After stirring for 5 h it was concentrated and codistilled twice with toluene to give the crude product. Yield: 1.58 g

Workup

  1. concentrationwas concentrated

Sources & evidence

ORD record
ord-b708dddeda474564ae0fb975864f6f26
Source dataset
uspto-grants-2013_04
Patent number
US08426420B2

Reaction notes

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