Trifluoroacetic acid → HCID 66856998, compound

HRID 1970592Notes

Reaction equation

HRID 1970592 reaction equation
C([O:5][C:6](=[O:39])[C@H:7]([NH:9][C:10]([C:12]1[CH:16]=[C:15]([O:17][CH2:18][C:19]([N:21]2[CH2:25][CH2:24][CH2:23][C@H:22]2[C:26](=[O:32])[NH:27][CH:28]2[CH2:31][CH2:30][CH2:29]2)=[O:20])[N:14]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[N:13]=1)=[O:11])[CH3:8])(C)(C)C.C(O)(C(F)(F)F)=O>ClCCl>[CH:28]1([NH:27][C:26]([C@@H:22]2[CH2:23][CH2:24][CH2:25][N:21]2[C:19](=[O:20])[CH2:18][O:17][C:15]2[N:14]([C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=3)[N:13]=[C:12]([C:10]([NH:9][C@H:7]([CH3:8])[C:6]([OH:39])=[O:5])=[O:11])[CH:16]=2)=[O:32])[CH2:29][CH2:30][CH2:31]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66854996HCID 66854996, compound

Product 1

HCID 66856998HCID 66856998, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 745 mg (R)-2-({5-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]-1-phenyl-1H-pyrazole-3-carbonyl}-amino)-propionic acid tert-butyl ester in 5 ml dichloromethane were added 1.6 ml TFA. After stirring for 6 h it was concentrated and codistilled twice with toluene to give the crude product. Yield: 770 mg

Workup

  1. concentrationwas concentrated

Sources & evidence

ORD record
ord-20244465c0d54d9ea1f45d88178db43d
Source dataset
uspto-grants-2013_04
Patent number
US08426420B2

Reaction notes

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