Morpholine → HCID 66854150, compound

HRID 1970611Notes

Reaction equation

HRID 1970611 reaction equation
[CH:1]1([O:5][C:6]([N:8]2[CH2:13][CH2:12][N:11]([C:14](=[O:46])[C@@H:15]([NH:28]C(OCC3C4C=CC=CC=4C4C3=CC=CC=4)=O)[CH2:16][CH2:17][CH2:18][CH2:19][O:20][CH2:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH2:10][CH2:9]2)=[O:7])[CH2:4][CH2:3][CH2:2]1.N1CCOCC1>CN(C=O)C>[CH:1]1([O:5][C:6]([N:8]2[CH2:13][CH2:12][N:11]([C:14](=[O:46])[C@@H:15]([NH2:28])[CH2:16][CH2:17][CH2:18][CH2:19][O:20][CH2:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH2:10][CH2:9]2)=[O:7])[CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 66854519(S)-4-[6-Benzyloxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoyl]-piperazine-1-carboxylic acid cyclobutyl ester

Product 1

HCID 66854150HCID 66854150, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 726 mg (S)-4-[6-Benzyloxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoyl]-piperazine-1-carboxylic acid cyclobutyl ester in 4.0 ml DMF were added at room temperature 1.0 ml morpholine. After stirring for 2 h the reaction mixture was evaporated and the crude product thus obtained used in the next step without further purification.

Workup

  1. customwas evaporated

Sources & evidence

ORD record
ord-98be4198bdab49c5ad3632aff4d2b3e6
Source dataset
uspto-grants-2013_04
Patent number
US08426420B2

Reaction notes

Loading…