(S)-2-(1-Benzyl-1H-tetrazol-5-yl)-pyrrolidine-1-carboxylic acid benzyl ester → HCID 178420796, compound

HRID 1970650Notes

Reaction equation

HRID 1970650 reaction equation
C(OC([N:11]1[CH2:15][CH2:14][CH2:13][C@H:12]1[C:16]1[N:20](CC2C=CC=CC=2)[N:19]=[N:18][N:17]=1)=O)C1C=CC=CC=1>C(O)C.[OH-].[OH-].[Pd+2]>[NH:11]1[CH2:15][CH2:14][CH2:13][C@H:12]1[C:16]1[NH:20][N:19]=[N:18][N:17]=1

Participants

4

Reactant 1

HCID 66857129(S)-2-(1-Benzyl-1H-tetrazol-5-yl)-pyrrolidine-1-carboxylic acid benzyl ester

Product 1

HCID 178420796HCID 178420796, compound

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 702EthanolSolvent

Procedure

To a solution of 494 mg (S)-2-(1-Benzyl-1H-tetrazol-5-yl)-pyrrolidine-1-carboxylic acid benzyl ester in 50 ml ethanol were added 100 mg Pd(OH)2/C (10%) and the suspension stirred under an atmosphere of hydrogen (4 bar) for 6 h. The reaction mixture was filtrated over a plug of Celite® and washed with ethanol. Yield: 173 mg colorless foam.

Workup

  1. filtrationThe reaction mixture was filtrated over a plug of Celite®
  2. washwashed with ethanol

Sources & evidence

ORD record
ord-9646b31769ff4df9a809b50e644cc7e5
Source dataset
uspto-grants-2013_04
Patent number
US08426420B2

Reaction notes

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