1,1'-Carbonyldiimidazole → 5-Methyloxazolo[4,5-b]pyridin-2(3H)-one

HRID 1970857Notes

Reaction equation

HRID 1970857 reaction equation
[NH2:1][C:2]1[C:7]([OH:8])=[CH:6][CH:5]=[C:4]([CH3:9])[N:3]=1.[C:10](N1C=CN=C1)(N1C=CN=C1)=[O:11]>>[CH3:9][C:4]1[N:3]=[C:2]2[NH:1][C:10](=[O:11])[O:8][C:7]2=[CH:6][CH:5]=1

Participants

3

Reactant 2

HCID 682631,1'-CarbonyldiimidazoleHCID 885002-Amino-6-methylpyridin-3-ol

Product 1

HCID 100120755-Methyloxazolo[4,5-b]pyridin-2(3H)-one

Procedure

Reaction of 2-amino-6-methylpyridin-3-ol with CDI (carbonyldiimidazole) in a corresponding manner to Example 1.2 gives the desired product; ESI: 151 (M+H), Rt=1.58 min (method B).

Sources & evidence

ORD record
ord-e11facff899746608cbb23af0edfb077
Source dataset
uspto-grants-2013_04
Patent number
US08431572B2

Reaction notes

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