反应详情

26.15 g (156 mmol) of 1-(3-nitrophenyl)ethanol are dissolved in 130 ml of glacial acetic acid, and 55 ml (313 mmol) of 33% HBr in glacial acetic acid are added dropwise with ice cooling. The reaction mixture is stirred at room temperature for 5 days. The mixture is subsequently diluted with 300 ml of DCM, washed with 3×200 ml of H2O and 200 ml of saturated NaHCO3 solution, dried over sodium sulfate and evaporated to dryness, and the residue is crystallised from petroleum ether.

1. washwashed with 3×200 ml of H2O and 200 ml of saturated NaHCO3 solution
2. dry with materialdried over sodium sulfate
3. customevaporated to dryness
4. customthe residue is crystallised from petroleum ether