反应详情

温度

100 °C

1.1 g (3.24 mmol) of methyl 2-oxo-3-(2-oxo-2,3-dihydro-1H-benzimidazol-5-ylmethyl)-2,3-dihydrobenzoxazole-5-carboxylate are suspended in 20 ml of water, 30 ml of conc. hydrochloric acid are added, and the mixture is stirred at a bath temperature of 100° C. for 24 h. A further 20 ml of conc. HCl are added, and the reaction mixture is stirred at a bath temperature of 130° C. for 3 days. The suspension is filtered and washed with water, and the residue is dried at 50° C. in a drying cabinet; product; 996 mg; m.p. 230-231° C.; ESI 326; HPLC: Rt=4.24 min (method A).

1. stirringthe reaction mixture is stirred at a bath temperature of 130° C. for 3 days
2. filtrationThe suspension is filtered
3. washwashed with water
4. customthe residue is dried at 50° C. in a drying cabinet