Cyclobutylamine → HCID 135995051, compound

HRID 1970905Notes

Reaction equation

HRID 1970905 reaction equation
[Cl:1][C:2]1[CH:19]=[CH:18][C:5]([CH2:6][C:7]2[NH:8][C:9](=[O:17])[C:10]([C:15]#[N:16])=[C:11](SC)[N:12]=2)=[CH:4][CH:3]=1.[CH:20]1([NH2:24])[CH2:23][CH2:22][CH2:21]1>>[Cl:1][C:2]1[CH:19]=[CH:18][C:5]([CH2:6][C:7]2[NH:8][C:9](=[O:17])[C:10]([C:15]#[N:16])=[C:11]([NH:24][CH:20]3[CH2:23][CH2:22][CH2:21]3)[N:12]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 75645CyclobutylamineHCID 58407870HCID 58407870, compound

Product 1

HCID 135995051HCID 135995051, compound

Procedure

In analogy to the preparation of Example 1, 100 mg (0.34 mmol) of 2-(4-chlorobenzyl)-4-(methyl-sulphanyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile are reacted with 244 mg (3.43 mmol) of cyclobutylamine to give 15 mg (14% of theory) of the title compound.

Sources & evidence

ORD record
ord-93f29a33d72c416e8afcb69f9e775ad5
Source dataset
uspto-grants-2013_04
Patent number
US08431573B2

Reaction notes

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