Piperidine → HCID 135995005, compound

HRID 1970908Notes

Reaction equation

HRID 1970908 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][CH:19]=1)[CH2:5][C:6]1[NH:7][C:8](=[O:16])[C:9]([C:14]#[N:15])=[C:10](SC)[N:11]=1.[NH:20]1[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1>>[F:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][CH:19]=1)[CH2:5][C:6]1[NH:7][C:8](=[O:16])[C:9]([C:14]#[N:15])=[C:10]([N:20]2[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]2)[N:11]=1

Participants

3

Reactant 2

HCID 8082PiperidineHCID 58407924HCID 58407924, compound

Product 1

HCID 135995005HCID 135995005, compound

Procedure

In analogy to the preparation of Example 1, 100 mg (0.36 mmol) of 2-(3-fluorobenzyl)-4-(methyl-sulphanyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile are reacted with 309 mg (3.63 mmol) of piperidine to give 40 mg (35% of theory) of the title compound.

Sources & evidence

ORD record
ord-fef23d61ae334aaea2844431c6c0d865
Source dataset
uspto-grants-2013_04
Patent number
US08431573B2

Reaction notes

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