Piperidine → HCID 135995084, compound

HRID 1970909Notes

Reaction equation

HRID 1970909 reaction equation
CS[C:3]1[N:4]=[C:5]([CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[CH:14]=2)[NH:6][C:7](=[O:11])[C:8]=1[C:9]#[N:10].[NH:23]1[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]1>>[O:11]=[C:7]1[NH:6][C:5]([CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[CH:14]=2)=[N:4][C:3]([N:23]2[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]2)=[C:8]1[C:9]#[N:10]

Participants

3

Reactant 2

HCID 8082PiperidineHCID 58407891HCID 58407891, compound

Product 1

HCID 135995084HCID 135995084, compound

Procedure

In analogy to the preparation of Example 1, 100 mg (0.31 mmol) of 4-(methylsulphanyl)-6-oxo-2-[3-(trifluoromethyl)benzyl]-1,6-dihydropyrimidine-5-carbonitrile are reacted with 262 mg (3.07 mmol) of piperidine to give 26 mg (22% of theory) of the title compound.

Sources & evidence

ORD record
ord-bbda3c089a614fdd8d0eea1f62f66061
Source dataset
uspto-grants-2013_04
Patent number
US08431573B2

Reaction notes

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