Isopropanol → HCID 44198068, compound

HRID 1970951Notes

Reaction equation

Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=2)[N:5]=[C:4]([C:14]2[CH:15]=[C:16]([C:20]3[CH:25]=[CH:24][C:23]([C:26]([N:28]4[CH2:33][CH2:32][N:31]([CH:34]([CH3:36])[CH3:35])[CH2:30][CH2:29]4)=[O:27])=[CH:22][CH:21]=3)[CH:17]=[N:18][CH:19]=2)[CH:3]=1.[CH:37]([OH:40])([CH3:39])[CH3:38]>>[CH:37]([O:40][C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=2)[N:5]=[C:4]([C:14]2[CH:15]=[C:16]([C:20]3[CH:25]=[CH:24][C:23]([C:26]([N:28]4[CH2:33][CH2:32][N:31]([CH:34]([CH3:36])[CH3:35])[CH2:30][CH2:29]4)=[O:27])=[CH:22][CH:21]=3)[CH:17]=[N:18][CH:19]=2)[CH:3]=1)([CH3:39])[CH3:38]

Participants

Reactant 2

HCID 3776Isopropanol

HCID 44197664HCID 44197664, compound

Product 1

HCID 44198068HCID 44198068, compound

Procedure

This compound is prepared from {4-[5-(6-chloro-2-pyridin-2-yl-pyrimidin-4-yl)-pyridin-3-yl]-phenyl}-(4-isopropyl-piperazin-1-yl)-methanone (Ex. 1) and isopropanol analogously to Example 2: [M+H]+=523 as a pale yellow solid.

Sources & evidence

ORD record: ord-c7f33167c97c4240a87dc4cb63060901
Source dataset: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08431578B2

Reaction notes

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