Ammonium Chloride → 6-Methylpicolinimidamide

HRID 1970958Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1970958
CO[NH:3][C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH3:12])[N:7]=1)=[NH:5].[Cl-].[NH4+]>CCO.O>[CH3:12][C:8]1[N:7]=[C:6]([C:4]([NH2:5])=[NH:3])[CH:11]=[CH:10][CH:9]=1

Komponenten

5

Edukt 2

HCID 25517Ammonium ChlorideHCID 178502857HCID 178502857, Verbindung

Produkt 1

HCID 142532006-Methylpicolinimidamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

To a solution of N-methoxy-6-methyl-pyridine-2-carboxamidine (1 eq, 32.9 mmol, 4.94 g) in EtOH (40 ml) and water (10 ml) at room temperature is added ammonium chloride (1 eq, 32.9 mmol, 1.76 g). The resulting mixture is heated to 80° C. for 4 hours and then allowed to cool to room temperature overnight. The solvent is removed in vacuo to afford the title compound which is used in subsequent steps without further purification [2M+H]+=271

Aufarbeitung

  1. temperatureto cool to room temperature overnight
  2. customThe solvent is removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-9f32abd0bb3d4ae4b8fe76438283a693
Quelldatensatz
uspto-grants-2013_04
Patentnummer
US08431578B2

Notizen zur Reaktion

Wird geladen…