反应详情

A solution of 6-methyl-pyridine-2-carboxamidine (step 2) (1.2 eq, 8.23 mmol, 1.41 g) in MeOH (5 ml) under an inert atmosphere of argon, at room temperature is treated with dimethyl malonate (1 eq, 6.86 mmol, 1.04 ml) and 0.5 M sodium methoxide in MeOH (3eq, 20.6 mmol, 41.2 ml). The resulting mixture is heated at reflux overnight and then allowed to cool to room temperature. The mixture is dry loaded onto silica and purification by flash chromatography eluting with 0-5% MeOH in DCM affords the title compound as a pale yellow solid [M+H]+=204.

1. temperatureThe resulting mixture is heated
2. temperatureat reflux overnight
3. customThe mixture is dry loaded onto silica and purification by flash chromatography
4. washeluting with 0-5% MeOH in DCM