反应详情

To a stirred solution of N-(dicyclopropylmethyl)-2-methylpropane-2-sulfinamide (86 g, 400 mmol) in MeOH (200 mL) was added 4 N HCl in dioxane (200 mL, 800 mmol). The reaction mixture was left to stir for 30 min, concentrated to half the volume, and diluted with Ether. The white precipitate was filtered through a fritted glass, washed with ether, and dried under high-vacuum to give the title compound. 1H NMR (600 MHz, CD3SOCD3) δ 8.17 (br s, 3H); 1.89 (t, 1H); 1.02 (m, 2H); 0.54 (m, 2H); 0.48 (m, 2H); 0.39 (m, 4H).

1. waitThe reaction mixture was left
2. concentrationconcentrated to half the volume
3. additiondiluted with Ether
4. filtrationThe white precipitate was filtered through a fritted glass
5. washwashed with ether
6. customdried under high-vacuum