Sulfuric acid magnesium salt (1:1) → HCID 59543125, compound

HRID 1970969Notes

Reaction equation

HRID 1970969 reaction equation
CO[CH:3](OC)[CH2:4][C:5]([CH3:8])([OH:7])[CH3:6].[CH3:11][C:12]([S:15]([NH2:17])=[O:16])([CH3:14])[CH3:13].S([O-])([O-])(=O)=O.[Mg+2].CC1C=CC(S(O)(=O)=O)=CC=1.O>C(Cl)Cl>[OH:7][C:5]([CH3:8])([CH3:6])[CH2:4]/[CH:3]=[N:17]/[S:15]([C:12]([CH3:14])([CH3:13])[CH3:11])=[O:16]

Participants

6

Reactant 4

HCID 24083Sulfuric acid magnesium salt (1:1)HCID 521998p-Toluenesulfonic acid monohydrateHCID 3382465Tert-ButanesulfinamideHCID 44399804,4-Dimethoxy-2-methylbutan-2-ol

Product 1

HCID 59543125HCID 59543125, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirred solution of 4,4-dimethoxy-2-methylbutan-2-ol (2.49 g, 16.8 mmol) in DCM (35 mL) were added 2-methyl-2-propanesulfinamide (1.7 g, 14 mmol), magnesium sulfate (8.44 g, 70.1 mmol), and pTsOH.H2O (0.13 g, 0.70 mmol). The reaction mixture was left to stir overnight, filtered through a fritted glass, concentrated, and purified by flash chromatography to give the title compound.

Workup

  1. waitThe reaction mixture was left
  2. filtrationfiltered through a fritted glass
  3. concentrationconcentrated
  4. custompurified by flash chromatography

Sources & evidence

ORD record
ord-c920264e7c3041fab1be82379a652cd8
Source dataset
uspto-grants-2013_04
Patent number
US08431569B2

Reaction notes

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