Hydrochloric Acid → HCID 67529179, compound

HRID 1970971Notes

Reaction equation

HRID 1970971 reaction equation
[CH:1]1([CH:4]([NH:10]S(C(C)(C)C)=O)[CH2:5][C:6]([OH:9])([CH3:8])[CH3:7])[CH2:3][CH2:2]1.[ClH:17].O1CCOCC1>CO>[Cl-:17].[CH:1]1([CH:4]([NH3+:10])[CH2:5][C:6]([OH:9])([CH3:8])[CH3:7])[CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 59543159HCID 59543159, compound

Product 1

HCID 67529179HCID 67529179, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a stirred solution of N-(1-cyclopropyl-3-hydroxy-3-methylbutyl)-2-methylpropane-2-sulfinamide (0.56 g, 2.26 mmol) in MeOH (1.2 mL) was added 4 N HCl in dioxane (1.1 mL, 4.4 mmol). The reaction mixture was left to stir for 30 min, concentrated, and dried under high-vacuum to give the title compound. 1H NMR (600 MHz, CD3SOCD3) δ 7.75 (br s, 3H); 2.54 (m, 1H); 1.77 (dd, 1H); 1.65 (dd, 1H); 1.19 (s, 3H); 1.14 (s, 3H); 0.96 (m, 1H); 0.53 (m, 3H); 0.26 (m, 1H).

Workup

  1. waitThe reaction mixture was left
  2. concentrationconcentrated
  3. customdried under high-vacuum

Sources & evidence

ORD record
ord-d591d46e96c14a22bb3fa0d2d7ba46ad
Source dataset
uspto-grants-2013_04
Patent number
US08431569B2

Reaction notes

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