HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 59543137, compound → 4-{[tert-Butyl(dimethyl)silyl]oxy}-3-fluorocyclohexanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 59543137 | HCID 59543137 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-{[tert-Butyl(dimethyl)silyl]oxy}-3-fluorocyclohexanamine | HCID 59543122 | — |
Reaction Steps
To a stirred solution [(4-azido-2-fluorocyclohexyl)oxy](tert-butyl)dimethylsilane (1.0 g, 3.66 mmol) in MeOH (15 mL) was added Pd/C in MeOH. The flask was evacuated and filled with hydrogen several times, and left to stir overnight under hydrogen atmosphere. The mixture was diluted with DCM, filtered through a pad of Celite, and concentrated to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08431569B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-8bae95b7b94349f9b70c918431b8eece |
| Source note | uspto-grants-2013_04 |