反应详情

温度

85 °C

A flask containing 1,7-dichloro-5H-pyrido[4,3-b]indole-4-carbonitrile (Example 1 Step 4, 140 mg, 0.53 mmol), BINAP (50 mg, 0.08 mmol), Pd2(dba)3 (24 mg, 0.03 mmol), and NaOtBu (164 mg, 1.71 mmol) was evacuated and refilled with nitrogen (×3). Degassed DME (10 mL) and (7R,8R)-7-methyl-1,4-dioxaspiro[4.5]decan-8-amine (183 mg, 1.07 mmol) were added to the mixture. The reaction mixture was heated to 85° C. overnight, cooled to room temperature, diluted with EtOAc, and washed with water and brine. The organic layer was dried (sodium sulfate), concentrated, and purified by flash chromatography to afford the title compound. LRMS (APCI) calc'd for (C21H21ClN4O2) [M+H]+, 397.1. found 397.0.

1. customwas evacuated
2. additionrefilled with nitrogen (×3)
3. temperaturecooled to room temperature
4. washwashed with water and brine
5. dry with materialThe organic layer was dried (sodium sulfate)
6. concentrationconcentrated
7. custompurified by flash chromatography