Pyrazole → 4-(1H-Pyrazol-1-yl)aniline

HRID 1971230Notes

Reaction equation

HRID 1971230 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-])=O)=[CH:4][CH:3]=1.[NH:11]1[CH:15]=[CH:14][CH:13]=[N:12]1>>[N:11]1([C:2]2[CH:7]=[CH:6][C:5]([NH2:8])=[CH:4][CH:3]=2)[CH:15]=[CH:14][CH:13]=[N:12]1

Participants

3

Reactant 2

HCID 1048PyrazoleHCID 9590p-Fluoronitrobenzene

Product 1

HCID 5942744-(1H-Pyrazol-1-yl)aniline

Procedure

The title compound is obtained as described in Example 18a/b using 1-fluoro-4-nitrobenzene (Fluka, Buchs, Switzerland) and 1H-pyrazole (Fluka, Buchs, Switzerland). Title compound: ES-MS: 160.2 (M+H)+; analytical HPLC: tret=3.61 minutes (Grad 2).

Sources & evidence

ORD record
ord-d33d97d2c8ae4bf89b7d3b8316e3683a
Source dataset
uspto-grants-2013_04
Patent number
US08431592B2

Reaction notes

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