HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → Imidazo(1,2-a)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Reactant | 6-Aminopyridine-2-carboxylic acid | HCID 351652 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Imidazo(1,2-a)pyridine | HCID 78960 | — |
Reaction Steps
In Scheme 2, 2-amino-6-pyridine carboxylic acid 8 is reacted with an amine 9 using a coupling agent such as, but not limited to, BOP or DMC in an organic solvent such as DCM or DMF in the presence of an organic base such as Hunig's base. The resulting amide 10 is reacted with alpha halocarbonyl 11 to give the imidazo[1,2-a]pyridine 12. Alternatively 10 can be reacted with the alpha haloaldehyde 13 to give the imidazo[1,2-a]pyridine 14.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08431593B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-96b0d1e03ad64ed2a4f955b004a2a723 |
| Source note | uspto-grants-2013_04 |