HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylacetamide → HCID 59451918, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylacetamide | HCID 31374 | — |
| Reactant | Tricyclo(3.3.1.13,7)dec-1-ylmethylamine | HCID 86625 | — |
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Reactant | 6-Aminopyridine-2-carboxylic acid | HCID 351652 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 59451918 | HCID 59451918 | — |
Reaction Steps
To a suspension of 6-aminopyridine-2-carboxylic acid (10 g, 72.4 mmol) in DMF (200 mL) at RT, is sequentially added 25.2 mL of DMA (144.8 mmol), 12 g of 1-admantylmethylamine (72.4 mmol) and 38.4 g of BOP (86.88 mmol). The resulting mixture is stirred at RT for 16 h. The reaction mixture is added to 400 mL of ice/water. Filtration affords the title compound which is used in subsequent reactions without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08431593B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-418399044e2d4c93b3d25ea2b46c943f |
| Source note | uspto-grants-2013_04 |