HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,4-Dioxin | HCID 78968 | — |
| Reactant | HCID 59451896 | HCID 59451896 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | HCID 59451905 | HCID 59451905 | — |
Reaction Steps
A solution of tert-butyl [(3R)-1-({5-[(adamantan-1-ylmethyl)carbamoyl]imidazo[1,2-a]pyridin-2-yl}methyl)pyrrolidin-3-yl]carbamate (411 mg, 0.81 mmol) in MeOH (4 mL) is treated with 2 mL of HCl solution in 1,4-dioxine (4.0 M, 8 mmol) for 16 h at RT. The solvent is removed in vacuo to give the title compound as its HCl salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08431593B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-c0c7aa2dd3d84faaa71d015ac9343905 |
| Source note | uspto-grants-2013_04 |