Hydrochloric Acid → Hydrochloric Acid

HRID 1971250Notes

Reaction equation

HRID 1971250 reaction equation
[C:1]12([CH2:11][NH:12][C:13]([C:15]3[N:20]4[CH:21]=[C:22]([CH2:24][N:25]5[CH2:29][CH2:28][C@@H:27]([NH:30]C(=O)OC(C)(C)C)[CH2:26]5)[N:23]=[C:19]4[CH:18]=[CH:17][CH:16]=3)=[O:14])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[ClH:38].O1C=COC=C1>CO>[C:1]12([CH2:11][NH:12][C:13]([C:15]3[N:20]4[CH:21]=[C:22]([CH2:24][N:25]5[CH2:29][CH2:28][C@@H:27]([NH2:30])[CH2:26]5)[N:23]=[C:19]4[CH:18]=[CH:17][CH:16]=3)=[O:14])[CH2:8][CH:7]3[CH2:9][CH:3]([CH2:4][CH:5]([CH2:6]3)[CH2:10]1)[CH2:2]2.[ClH:38]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 789681,4-DioxinHCID 59451896HCID 59451896, compound

Product 2

HCID 313Hydrochloric AcidHCID 59451905HCID 59451905, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of tert-butyl [(3R)-1-({5-[(adamantan-1-ylmethyl)carbamoyl]imidazo[1,2-a]pyridin-2-yl}methyl)pyrrolidin-3-yl]carbamate (411 mg, 0.81 mmol) in MeOH (4 mL) is treated with 2 mL of HCl solution in 1,4-dioxine (4.0 M, 8 mmol) for 16 h at RT. The solvent is removed in vacuo to give the title compound as its HCl salt.

Workup

  1. customThe solvent is removed in vacuo

Sources & evidence

ORD record
ord-c0c7aa2dd3d84faaa71d015ac9343905
Source dataset
uspto-grants-2013_04
Patent number
US08431593B2

Reaction notes

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