反应详情

To a solution of {5-[(adamantan-1-ylmethyl)-carbamoyl]-imidazo[1,2-a]pyridin-2-yl}-acetic acid ethyl ester (65 mg, 0.16 mmol) in THF (5 mL) at RT, is added portion-wise LiBH4 (10 mg, 0.46 mmol). The resulting mixture is stirred at RT for 16 h. The reaction is quenched by the slow addition of water, followed by the addition of EtOAc. The organic layer is separated, and the aqueous layer is back extracted with EtOAc. The combined organic layers are washed with water and brine, dried over sodium sulfate, and concentrated. Purification of the residue by PTLC (10% MeOH in DCM) the title compound.

1. customThe reaction is quenched by the slow addition of water
2. additionfollowed by the addition of EtOAc
3. customThe organic layer is separated
4. extractionthe aqueous layer is back extracted with EtOAc
5. washThe combined organic layers are washed with water and brine
6. dry with materialdried over sodium sulfate
7. concentrationconcentrated
8. customPurification of the residue by PTLC (10% MeOH in DCM) the title compound