Ammonium Acetate → 1,3-Thiazol-2-ylthiourea

HRID 1971441Notes

Reaction equation

HRID 1971441 reaction equation
[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[NH:6][C:7]([N:9]1C=CN=C1)=[S:8].C([O-])(=O)C.[NH4+]>C(O)C>[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[NH:6][C:7]([NH2:9])=[S:8]

Participants

4

Reactant 2

HCID 517165Ammonium AcetateHCID 10750950N-(thiazol-2-yl)-1H-imidazole-1-carbothioamide

Product 1

HCID 27710081,3-Thiazol-2-ylthioureaYield 121.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 65 g (309.1 mmol) N-1,3-thiazole-2-yl-1H-imidazole-1-carbothioamide and 260 g of ammonium acetate were heated to 80° C. in 400 ml ethanol for 1.5 hours; after completion of reaction the solvent was distilled off and water was added to the obtained residue. After extraction with CH2Cl2 and drying of the organic phase with Na2SO4, 59.6 g of the target product were obtained.

Workup

  1. customafter completion of reaction the solvent
  2. distillationwas distilled off
  3. additionwater was added to the obtained residue
  4. extractionAfter extraction with CH2Cl2
  5. dry with materialdrying of the organic phase with Na2SO4

Sources & evidence

ORD record
ord-bf35adfbf8df4464b5735cef14e6b56c
Source dataset
uspto-grants-2013_04
Patent number
US08431604B2

Reaction notes

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