1-Methylpiperazine → HCID 68707573, compound

HRID 1971545Notes

Reaction equation

HRID 1971545 reaction equation
[O:1]1[C:6]2[CH:7]=[CH:8][C:9]([C:11]3[N:16]4[N:17]=[C:18]([NH:20][C:21](=[O:24])[CH:22]=[CH2:23])[N:19]=[C:15]4[CH:14]=[CH:13][CH:12]=3)=[CH:10][C:5]=2[O:4][CH2:3][CH2:2]1.C[N:26]1[CH2:31]C[NH:29][CH2:28][CH2:27]1>C(O)C>[O:1]1[C:6]2[CH:7]=[CH:8][C:9]([C:11]3[N:16]4[N:17]=[C:18]([NH:20][C:21](=[O:24])[CH2:22][CH2:23][N:26]5[CH:27]=[CH:28][N:29]=[CH:31]5)[N:19]=[C:15]4[CH:14]=[CH:13][CH:12]=3)=[CH:10][C:5]=2[O:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 59589531HCID 59589531, compound

Product 1

HCID 68707573HCID 68707573, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of N-[5-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-acrylamide (0.05 g, 0.155 mmol) in ethanol (2 mL) was added N-methylpiperazine (0.13 g, 1.86 mmol) and the solution was stirred overnight. The reaction mixture was purified by prep LCMS. LCMS Method: 2, RT: 2.09 min, MI: 423 [M+1].

Workup

  1. customThe reaction mixture was purified by prep LCMS

Sources & evidence

ORD record
ord-532199004eed4676abfec2877dc89c66
Source dataset
uspto-grants-2013_04
Patent number
US08431596B2

Reaction notes

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