Water → HCID 59589689, compound

HRID 1971599Notes

Reaction equation

HRID 1971599 reaction equation
Br[C:2]1[N:7]2[N:8]=[C:9]([NH2:11])[N:10]=[C:6]2[CH:5]=[CH:4][CH:3]=1.[CH:12]1([NH2:17])[CH2:16][CH2:15][CH2:14][CH2:13]1.O>CC(N(C)C)=O>[CH:12]1([NH:17][C:2]2[N:7]3[N:8]=[C:9]([NH2:11])[N:10]=[C:6]3[CH:5]=[CH:4][CH:3]=2)[CH2:16][CH2:15][CH2:14][CH2:13]1

Participants

5

Reactant 3

HCID 962WaterHCID 2906CyclopentylamineHCID 252159395-Bromo-[1,2,4]triazolo[1,5-a]pyridin-2-amine

Product 1

HCID 59589689HCID 59589689, compound

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Conditions

Temperature
180 °C

Procedure

To a solution of 5-bromo-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine (0.5 g, 2.35 mmol) in dimethylacetamide (2 mL), cyclopentylamine (2.3 mL, 23.5 mmol) was added and the solution was heated under microwave irradiation (180° C., 180 min). The resulting mixture was dilluted with water and extracted into ethyl acetate. The organics were washed with water then brine, and dried over magnesium sulfate. The solid (0.5 g) was used without further purification. LCMS1: 2.84 min, 218 [M+1].

Workup

  1. extractionextracted into ethyl acetate
  2. washThe organics were washed with water
  3. dry with materialbrine, and dried over magnesium sulfate
  4. customThe solid (0.5 g) was used without further purification
  5. custom2.84 min, 218 [M+1]

Sources & evidence

ORD record
ord-6d6cef1ed44e48bba1857a98f1771fba
Source dataset
uspto-grants-2013_04
Patent number
US08431596B2

Reaction notes

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