Tert-Butylamine → HCID 58124810, compound

HRID 1971642Notes

Reaction equation

HRID 1971642 reaction equation
CS(O[CH2:6][CH2:7][C:8]#[C:9][C:10]1[S:11][CH:12]=[CH:13][CH:14]=1)(=O)=O.[C:15]([NH2:19])([CH3:18])([CH3:17])[CH3:16]>>[C:15]([NH:19][CH2:6][CH2:7][C:8]#[C:9][C:10]1[S:11][CH:12]=[CH:13][CH:14]=1)([CH3:18])([CH3:17])[CH3:16]

Participants

3

Reactant 2

HCID 6385Tert-ButylamineHCID 86650570HCID 86650570, compound

Product 1

HCID 58124810HCID 58124810, compound

Procedure

A solution of 1 g of 1b in 10 ml of tert-BuNH2 was stirred overnight at RT. The mixture, consisting of desired product as well as elimination product, was concentrated, diluted with 20 ml of 5% NaHCO3 and extracted with ether. The extract was dried and concentrated (45° C./100 mm). The residue (˜450 mg) containing 1c was used without further purification in the next step;

Sources & evidence

ORD record
ord-82ebba91f33242d8afa6c9ee7271d010
Source dataset
uspto-grants-2013_04
Patent number
US08431564B2

Reaction notes

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