反应详情

A solution of 1 g of 1b in 10 ml of tert-BuNH2 was stirred overnight at RT. The mixture, consisting of desired product as well as elimination product, was concentrated, diluted with 20 ml of 5% NaHCO3 and extracted with ether. The extract was dried and concentrated (45° C./100 mm). The residue (˜450 mg) containing 1c was used without further purification in the next step;